发明名称 |
Identification, optimization and use of cryptic HLA-B7 epitopes for immunotherapy |
摘要 |
The invention provides methods for identifying a HLA-B*0702-restricted cryptic epitope in an antigen, as well as methods for increasing the immunogenicity of HLA-B*0702-restricted cryptic epitopes. The HLA-B*0702-restricted cryptic epitopes and their cognate immunogenic epitopes are useful for stimulating an immune reaction against the cryptic epitopes in a subject. Accordingly, the invention further provides pharmaceutical compositions comprising a HLA-B*0702-restricted cryptic epitope or a cognate immunogenic epitope thereof, and vaccination kits comprising such epitopes. The novel materials of the invention are particularly useful for efficiently treating patients having an HLA-B*0702 phenotype.
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申请公布号 |
US8465747(B2) |
申请公布日期 |
2013.06.18 |
申请号 |
US20070373408 |
申请日期 |
2007.07.12 |
申请人 |
KOSMATOPOULOS KOSTANTINOS (KOSTAS);GRAFF-DUBOIS STEPHANIE;MENEZ-JAMET JEANNE;VAXON BIOTECH |
发明人 |
KOSMATOPOULOS KOSTANTINOS (KOSTAS);GRAFF-DUBOIS STEPHANIE;MENEZ-JAMET JEANNE |
分类号 |
A61K38/03;A61K38/16;A61K39/395;C07K7/00;C07K14/00 |
主分类号 |
A61K38/03 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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