发明名称 |
Anti-CD19 antibodies with reduced immunogenicity |
摘要 |
<p>Pharmaceutical compositions comprising specific anti-CD19 B4 antibodies with modified variable regions in combination with chemotherapeutic agents are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response. Moreover the specific anti-CD19 antibodies are expressed in good yields in YB2/0 cells and elicit improved ADCC.</p> |
申请公布号 |
EP2270050(B1) |
申请公布日期 |
2013.06.05 |
申请号 |
EP20100008056 |
申请日期 |
2006.12.21 |
申请人 |
MERCK PATENT GMBH |
发明人 |
SUPER, MICHAEL;DAVIS, JONATHAN H.;STEIN, PASCAL ANDRE |
分类号 |
C07K16/28;A61K31/00;A61K39/395;A61P35/00;A61P37/04;C12N15/10;C12N15/13;C12N15/85 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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