发明名称 |
CRYSTAL STRUCTURE OF HUMAN ALPHA-N-ACETYLGLUCOSAMINIDASE |
摘要 |
The present invention provides the three-dimensional structure of human ±-N-acetylglucosaminidase (NAGLU) protein. This crystallographic information is useful in the identification and development of novel binding compounds of NAGLU, NAGLU mutants, for example, those associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)), and other NAGLU family members (family 89 ±- N- acetylglucosaminidase) which may modulate the activity and/or stability of mutated NAGLU. Such compounds may be useful for the treatment of Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)). |
申请公布号 |
EP2596123(A2) |
申请公布日期 |
2013.05.29 |
申请号 |
EP20110738141 |
申请日期 |
2011.07.22 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
MEIYAPPAN, MUTHURAMAN;CONCINO, MICHAEL, F.;NORTON, ANGELA, W. |
分类号 |
C12Q1/34;G01N33/573;G06F19/16;G06F19/18 |
主分类号 |
C12Q1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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