IMMUNOTHERAPEUTIC COMBINATIONS FOR THE TREATMENT OF TUMORS THAT OVER-EXPRESS GANGLIOSIDES

摘要

The invention relates to the field of immunology and specifically to immunotherapeutic combinations that are used to impede the growth of tumour cells and/or to eliminate said cells. The present invention can be used to observe a therapeutic antitumour effect by combining idiotypic vaccines having an antiganglioside antibody (Ab1) as the active principle thereof with idiotypic vaccines, the active principle of which is an anti-idiotype antibody obtained against an antiganglioside antibody (Ab2), or with vaccines, the active principle of which is one or more gangliosides. The invention relates to combinations of said vaccines which produce a synergism of the antitumour effect which is induced separately by each of the vaccines. Said combinations can be applied to patients in different clinical states with tumours that overexpress gangliosides.