<p>The present invention relates to a monoclonal antibody or an antibody fragment thereof, which binds to the extracellular region of human Trop-2 with high affinity and exhibits high ADCC activity and high antitumor activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent or a diagnostic agent using the antibody fragment thereof.</p>
申请公布号
EP2594589(A1)
申请公布日期
2013.05.22
申请号
EP20110792536
申请日期
2011.06.09
申请人
SAPPORO MEDICAL UNIVERSITY;KYOWA HAKKO KIRIN CO., LTD.