发明名称 |
Bispecific binding agents for modulating biological activity |
摘要 |
Methods for improving the biological and pharmaceutical properties of bispecific binding agents are described herein where the bispecific binding agents are able to target cells by a high affinity binding domain to a first cell surface marker that does not induce a significant biological effect and a low affinity binding domain that binds specifically to a second cell surface marker, causing a significant and desired biological effect. Compositions of such bispecific binding agents, uses for them, and kits containing them are also provided.
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申请公布号 |
US8440192(B2) |
申请公布日期 |
2013.05.14 |
申请号 |
US201213352736 |
申请日期 |
2012.01.18 |
申请人 |
NIELSEN ULRIK B.;SCHOEBERL BIRGIT M.;MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
NIELSEN ULRIK B.;SCHOEBERL BIRGIT M. |
分类号 |
A61K39/00;A61K39/395;C07K16/30 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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