发明名称 |
Substituted quinazoline and pyrido-pyrimidine derivatives |
摘要 |
The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
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申请公布号 |
US8440662(B2) |
申请公布日期 |
2013.05.14 |
申请号 |
US201113285227 |
申请日期 |
2011.10.31 |
申请人 |
SMITH ROGER ASTBURY;THOMPSON SCOTT KEVIN;HOSAHALLI SUBRAMANYA;BEJUGAM MALLESHAM;NANDURI SRINIVAS;PANIGRAHI SUNIL KUMAR;MAHALINGAM NATARAJAN;ENDO PHARMACEUTICALS, INC. |
发明人 |
SMITH ROGER ASTBURY;THOMPSON SCOTT KEVIN;HOSAHALLI SUBRAMANYA;BEJUGAM MALLESHAM;NANDURI SRINIVAS;PANIGRAHI SUNIL KUMAR;MAHALINGAM NATARAJAN |
分类号 |
A61K31/535;C07D413/04;C07D413/14 |
主分类号 |
A61K31/535 |
代理机构 |
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