发明名称 |
Osmotic Device Containing Amantadine and an Osmotic Salt |
摘要 |
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is a sigmoidal release. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt. The osmotic device further includes a drug-containing coat external to the semipermeable membrane. The osmotic device can include one or more additional drugs in the core and/or the drug-containing coat. |
申请公布号 |
US2013115249(A1) |
申请公布日期 |
2013.05.09 |
申请号 |
US201213551755 |
申请日期 |
2012.07.18 |
申请人 |
VERGEZ JUAN A.;FAOUR JOAQUINA;PASTINI ANA C.;BIGATTI GUIDO S.;MEYER GLENN A.;FELEDER ETHEL C.;RICCI MARCELO A.;COPPARI MARCELO A.;BEFUMO MARCELO F.;OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT |
发明人 |
VERGEZ JUAN A.;FAOUR JOAQUINA;PASTINI ANA C.;BIGATTI GUIDO S.;MEYER GLENN A.;FELEDER ETHEL C.;RICCI MARCELO A.;COPPARI MARCELO A.;BEFUMO MARCELO F. |
分类号 |
A61K9/28 |
主分类号 |
A61K9/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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