发明名称 |
SUBSTITUTED 2-(4-HETEROCYCLYLBENZYL)ISOINDOLIN-1-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 |
摘要 |
In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin- 1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
CA2853826(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
CA20122853826 |
申请日期 |
2012.10.28 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
LINDSLEY, CRAIG W.;CONN, P. JEFFREY;WOOD, MICHAEL R.;HOPKINS, COREY R.;MELANCON, BRUCE J.;POSLUSNEY, MICHAEL S.;ENGERS, DARREN W. |
分类号 |
C07D403/10;A61K31/395;A61K31/403;A61K31/404;A61K31/4155;A61K31/4178;A61K31/428;A61K31/437;A61K31/4439;A61K31/444;A61K31/4725;A61P25/00;A61P25/28;C07D401/10;C07D401/14;C07D417/10;C07D471/04;C07D519/00 |
主分类号 |
C07D403/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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