发明名称 |
IMMUNOGLOBULIN FRAMEWORK WHICH DEMONSTRATES ENHANCED STABILITY IN INTRACELLULAR ENVIRONMENT AND METHOD FOR IDENTIFYING THE SAME |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions which can be used as frameworks for the creation of very stable and soluble single-chain Fv antibody fragments. <P>SOLUTION: These frameworks have been selected for intracellular performance and are thus ideally suited for the creation of scFv antibody fragments or scFv antibody libraries for applications where stability and solubility are limiting factors for the performance of antibody fragments, such as in the reducing environment of a cell. Such frameworks can also be used to identify highly conserved residues and consensus sequences which demonstrate enhanced solubility and stability. <P>COPYRIGHT: (C)2013,JPO&INPIT |
申请公布号 |
JP2013078343(A) |
申请公布日期 |
2013.05.02 |
申请号 |
JP20130019425 |
申请日期 |
2013.02.04 |
申请人 |
ESBATECH AN ALCON BIOMEDICAL RESEARCH UNIT LLC |
发明人 |
TISSOT KATHRIN;EWERT STEFAN;AUF DER MAUR ADRIAN;BARBERIS ALCIDE;ESCHER DOMINIK |
分类号 |
C12N15/09;C07K16/00;C07K16/18;C07K16/46;C12P21/08;C40B40/10 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|