发明名称 |
NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF |
摘要 |
<p>The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R1, R2, R4, R6, R7, R8, R9, and R10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders.</p> |
申请公布号 |
WO2013033246(A9) |
申请公布日期 |
2013.05.02 |
申请号 |
WO2012US52904 |
申请日期 |
2012.08.29 |
申请人 |
BRAINCELLS, INC.;HUTCHINSON, JOHN HOWARD;BLEICHER, LEO;COSFORD, NICK;ARDECKY, ROBERT JOHN;ZOU, JIWEN |
发明人 |
HUTCHINSON, JOHN HOWARD;BLEICHER, LEO;COSFORD, NICK;ARDECKY, ROBERT JOHN;ZOU, JIWEN |
分类号 |
C07D403/04;A61K31/5513;A61P25/00;C07D243/14;C07D409/14 |
主分类号 |
C07D403/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|