| 发明名称 |
INHIBITION OF HISTONE ACETYLTRANSFERASES BY CTK7A AND METHODS THEREOF |
| 摘要 |
The present disclosure relates to a method for inhibiting histone acetyltransferases by derivative of curcumin, particularly CTK7A. The present disclosure also relates to identification of induction of autoacetylation of p300 and its inhibition by CTK7A. The disclosure also relates to induction of NPM1 and GAPDH overexpression and corresponding hyperacetylation of histone and methods thereof. |
| 申请公布号 |
EP2475769(A4) |
申请公布日期 |
2013.04.24 |
| 申请号 |
EP20100813423 |
申请日期 |
2010.09.06 |
| 申请人 |
JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH |
发明人 |
KUNDU, TAPAS, KUMAR;ARIF, MOHAMMED;MANTELINGU, KEMPEGOWRA;SRINIVASACHAR, GOPINATH, KODAGANUR |
| 分类号 |
C12N9/10;A61K31/415;A61K38/45;A61P35/02;C12Q1/48;G01N33/53;G01N33/574;G01N33/68 |
主分类号 |
C12N9/10 |
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