IDENTIFICATION OF THE GENE NOTCH3 AS A NOVEL BIOMARKER FOR HUMAN METASTATIC MELANOMA

摘要

The present invention provides evidence that Notch3 gene upregulation is associated with invasive metastatic melanoma. Assays for quantifying Notch3 expression in biological samples and methods of use for diagnosis, and assaying progression and treatment outcome using these assays are also provided. Methods of screening for compounds which inhibit Notch3 expression are also provided.