Disclosed is a scheduling method for multi-user multiple input and multiple output (MU-MIMO), including: optimally pairing candidate users for the first to the nth resource to be allocated to obtain optimal user pairs for the first to the nth resource to be allocated respectively, with n being a positive integer; combining the optimal user pairs to obtain all the user pair groups formed by the optimal user pairs, and ensuring when combining the optimal user pairs that the same user in each obtained user pair group only exists in one optimal user pair; and allocating the first to the nth resource to be allocated to the optimal user pairs in the user pair group with most optimal user pairs. Also disclosed is a scheduling device. The application of the present invention can reduce the computation complexity during the scheduling process and improve the spectrum utilization rate.