| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide solid medicaments using vardenafil hydrochloride configured to solve the problem that is the defect of vardenafil hydrochloride in which solid medicaments cannot be prepared or isolated in pure form because they each take in a small amount of water and thus exist as the mixture of polymorph and hydrate, it is also possible for absorption to be reduced in the bioavailability (AUC), maximum plasma concentration (Cmax) and the appearance time of the maximum plasma concentration (AUCmax), and thereby, the effect thereof is improper or does not appear at all, and to provide the method for producing the solid medicament. <P>SOLUTION: In the method for producing medicaments containing vardenafil hydrochloride in solid form, vardenafil hydrochloride with any content of water is brought into contact with moistened gas, in the intermediate process stage thereof or in the final product or in a coated tablet until the trihydrate thereof is sufficiently formed. <P>COPYRIGHT: (C)2013,JPO&INPIT |
