发明名称 |
ORAL MICROEMULSION COMPOSITION COMPRISING BIPHENYLDIMETHYLDICARBOXYLATE AND SILYBIN |
摘要 |
<p>A microemulsion composition comprising biphenyldimethyldicarboxylate (BDD) and silybin or a derivative thereof, or a <i>Carduus marianus</i> extract containing silybin and derivatives thereof, as active ingredients; a co-surfactant; a surfactant; and an oil provides a synergistic therapeutic effect for liver diseases due to the complementary work of the two kinds of active ingredients having different working mechanisms without any adverse side effect or an antagonism, and high <i>in vivo</i> bioavailabilities of both of the active ingredients, when orally administered.</p> |
申请公布号 |
EP1682088(B1) |
申请公布日期 |
2013.04.03 |
申请号 |
EP20040793556 |
申请日期 |
2004.10.21 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
WOO, JONG SOO;JUNG, SI YOUNG;KIM, AE GUK |
分类号 |
A61K45/06;A61K9/107;A61K9/48;A61K31/19;A61K31/357;A61K36/28 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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