发明名称 |
PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF |
摘要 |
A process for preparing a 5-halophenol, ortho-substituted by an electron-donating group, is described. Also described, is a process for preparing a sulphonic ester of an ortho-substituted phenol, which is the synthesis intermediate for the ortho-substituted 5-halophenol. The process for preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester can include reacting a phenol ortho-substituted by an electron-donating group with a sulphonylating agent in the presence of a Lewis acid. The process for preparing a 5-halophenol ortho-substituted by an electron-donating group can include a first step of preparing a phenol ortho-substituted by an electron-donating group and protected in the form of a sulphonic ester, as described above; a second step of halogenating the protected phenol intermediate obtained in the preceding step, in the position para to the electron-donating group; and a third step of deprotecting the sulphonic ester function to hydroxyl. |
申请公布号 |
EP2574192(A1) |
申请公布日期 |
2013.04.03 |
申请号 |
EP20100851578 |
申请日期 |
2010.05.19 |
申请人 |
RHODIA (CHINA) CO., LTD.;RHODIA OPERATIONS |
发明人 |
MERCIER, CLAUDE;DE CAMPO, FLORYAN;RIGHINI, SEBASTIEN |
分类号 |
C07C309/12;C07C41/01;C07C43/253 |
主分类号 |
C07C309/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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