METHOD FOR THE PREPARATION OF MONTELUKAST ACID IN IONIC LIQUID MEDIUM

摘要

The present invention relates to a method for preparing Montelukast acid or
its sodium salt by reacting a thiol compound
with a Montelukast intermediate in the presence of a base in a medium
comprising an ionic liquid compound. In accordance
with the inventive method, highly pure Montelukast acid or its sodium salt,
which is advantageously used as a raw material in the
preparation of Montelukast, a leukotriene antagonist, can be easily prepared
in a high yield.