发明名称 |
Compositions and methods for inhibiting expression of a gene from the JC virus |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.
|
申请公布号 |
US8410261(B2) |
申请公布日期 |
2013.04.02 |
申请号 |
US201113252414 |
申请日期 |
2011.10.04 |
申请人 |
TAN PAMELA;SAH DINAH;BRAMLAGE BIRGIT;ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
TAN PAMELA;SAH DINAH;BRAMLAGE BIRGIT |
分类号 |
C07H21/02;A61K9/127;C12N5/00;C12N15/113 |
主分类号 |
C07H21/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|