摘要 |
<p>A preparation method of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide is provided, which includes the steps of preparing the crude product and crystallizing, wherein acetone and water are used as solvents in the step of crystallizing. The (S)-oxiracetam prepared by the method of the present invention has high purity of more than 99.3% and low impurity of 0-0.5%, based on the percentages of the mass. According to the method of the present invention, with regard to the way of charging materials, adding inorganic base only just a few times is easier to handle and more convenient to the industrial manufacturing and application.</p> |
申请人 |
CHONGQING RUNZE MEDICAL EQUIPMENT AND SUPPLIES CO., LTD |
发明人 |
CHEN, YUYING;RONG, ZUYUAN;JIN, LEI;FENG, HUA;LI, FEI;LI, BO;YOU, CHAO;PANG, QI;YE, LEI;XU, NAN |