发明名称 |
INTEGRIN ALPHA-2 BINDING AGENTS AND USE THEREOF TO INHIBIT CANCER CELL PROLIFERATION |
摘要 |
<p>The invention provides an integrin alpha-2 binding agent and methods of using an integrin alpha-2 binding agent to, e.g., inhibit proliferation of cancer cells, modulate tumor growth in a subject, inhibiting angiogenesis, or treating a fibrotic disorder. The invention further provides a method of producing an antibody, the method comprising propagating cancer cells in a 3-dimensional matrix; immunizing a mammal with the propagated cancer cells; and isolating an antibody from the immunized mammal. A method of identifying an agent that inhibits cancer cell proliferation also is provided.</p> |
申请公布号 |
WO2012158989(A9) |
申请公布日期 |
2013.03.21 |
申请号 |
WO2012US38476 |
申请日期 |
2012.05.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;WEISS, STEPHEN, J.;DUDLEY, DAVID, T. |
发明人 |
WEISS, STEPHEN, J.;DUDLEY, DAVID, T. |
分类号 |
C07K16/28;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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