发明名称 |
PYRAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY |
摘要 |
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
|
申请公布号 |
US2013072536(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
US201213675294 |
申请日期 |
2012.11.13 |
申请人 |
SYNTA PHARMACEUTICALS CORP.;SYNTA PHARMACEUTICALS CORP. |
发明人 |
YING WEIWEN;ZHANG SHIJIE;DU ZHENJIAN;FOLEY KEVIN |
分类号 |
A61K31/415;C07D231/20;C07D403/04 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|