THERAPEUTIC PEPTIDES

摘要

The present invention provides peptides which specifically react with B-subunit of Plasmodium falciparum vacuolar-H+ATPase (V-H+ ATPase). The peptides were identified by panning phage display peptide libraries with recombinant B subunit of P.falciparum V-H+ ATPase. The selected phages specifically react with P.falciparum infected cells and corresponding free peptides inhibit parasite growth in vitro. The identified peptides can be used for therapy of malaria and other diseases caused by pathogens expressing B subunit of V-H+ ATPase.