| 摘要 |
PURPOSE: A PI3K activation controlling agent containing a fifth zinc finger domain of FOG2 is provided to induce cancer cell apoptosis and to prevent and treat PI3K-associated diseases. CONSTITUTION: A polypeptide contains a fifth zinc finger domain of FOG2(Friend of GATA 2). The polypeptide has 20-500 amino acids. The polypeptide contains 547-570th amino acid sequence at N-terminal of FOG2 amino acid sequence of sequence number 1. An agent for anticancer or anticancer aid contains the polypeptide; a nucleic acid molecule encoding the polypeptide; or vector containing a nucleic acid molecule. A composition for preventing and treating metabolic disease contains the polypeptide, the nucleic acid encoding the polypeptide, or the vector. |
