LIVER-ACCUMULATIVE NANOPARTICLE HAVING DRUG ENCAPSULATED THEREIN

摘要

The purpose of the present invention is to provide a liver-accumulative nanoparticle having a drug encapsulated therein, in which the drug can be encapsulated therein with high efficiency and the drug can be enclosed therein stably, and which enables the facilitation of the accumulation of the drug in the liver. A drug-encapsulated nanoparticle produced by encapsulating a drug in a nanoparticle that comprises any one component selected from poly-DL, L-lactic acid and a poly(DL or L-lactic acid/glycolic acid) copolymer, a conjugate of arabinogalactan and a biodegradable cationic polymer, a metal ion and a basic low-molecular-weight compound, wherein the drug is, for example, an anti-hepatitis virus agent, a therapeutic agent for liver cancer or an agent for improving the function of the liver, and wherein the drug-encapsulated nanoparticle exhibits excellent accumulation in the liver and excellent sustainability.