Verfahren zur Herstellung von Aminoformylverbindungen

摘要

Process for the prepn. of cpds. where ac = acyl; X = disubstd. C atom; Ra= an alcohol residue; Ro= H or an acyl. Intermediates in the prepn. of pharmaceuticals, particularly 7-acylaminocephalosporanic acids. To (III) obtained by addn. of 6 g. of the corresponding malic ester in 100 ml. MeOCH2CH2OMe to 400 ml. refluxing octane and removal of 240 ml. solvent is added 1 g. (IV) and the mixt. is refluxed for 9 hrs. Evapn. and extn. with C6H6 gives crude (V), 1.158 g. of which is chromatographed on 45 g. silica gel, to give mainly isomer A, (alpha)D-122 deg.