| 摘要 |
The present invention concerns the compounds of formula wherein Z represents NH; Y represents—C3-9alkyl-,—C2-9alkenyl-,—C3-7alkyl-CO—NH optionally substituted with amino, mono- or di(C1-4alkyl)amino or C1-4alkyloxycarbonylamino-,—C3-7alkenyl-CO—NH—optionally substituted with amino, mono- or di(C1-4alkyl)amino- or C1-4alkyloxycarbonylamino-, C1-5alkyl-NR13—C1-5alkyl-,—C1-5alkyl-NR14—CO—C1-5alkyl-,—C1-6alkyl-CO—NH—,—C1-5alkyl-CONR15—C1-5alkyl-,—C1-3alkyl-NH—CO-Het20-,—C1-2alkyl-CO-Het21-CO—,—C1-2alkyl-NH—CO—CR16R17—NH—,—C1-2alkyl-CO—NH—CR18R19—CO—,—C1-2alkyl-CO—NR20—C1-3alkyl-CO—, or—NR22—CO—C1-3alkyl-NH—; X1 represents a direct bond, O or—O—C1-2alkyl-; X2 represents a direct bond,—CO—C1-2alkyl-, NR12,—NR12—C1-2alkyl-,—O—N═CH—or—C1-2alkyl-; R1 and R2 are hydrogen or halo; R3 are hydrogen; R4 represents hydrogen or C1-4alkyloxy; R12 and R13 are hydrogen or C1-4alkyl; R14 and R15 are hydrogen; R16 and R17 each independently represent hydrogen or C1-4alkyl; R18 and R19 are hydrogen or C1-4alkyl optionally substituted with phenyl or hydroxy; R20 and R21 are hydrogen or C1-4alkyl optionally substituted with C1-4alkyloxy; Het20, Het21 and Het22 are a heterocycle selected from the group consisting pyrrolidinyl, 2-pyrrolidinonyl or piperidinyl optionally substituted with hydroxy.
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