发明名称 TARGETED DELIVERY AND PRODRUG DESIGNS FOR PLATINUM-ACRIDINE ANTI-CANCER COMPOUNDS AND METHODS THEREOF
摘要 <p>Acridine containing cispiaiin compounds have been disclosed that show greater efficacy against cancer than other cisplatin compounds. Methods of delivery of those more effective eisp!aiin compounds to the nucleus in cancer ceils is disclosed using one or more amino acids, one or more sugars, one or more polymeric ethers, C i^aikylene-phenyl-NH-C(0)-R.15, folic acid, av03 iniegriii RGD binding peptide, tamoxifen, endoxifen, epidermal growth factor receptor, antibody conjugates, kinase inhibitors, diazoles, triazol.es, oxazoies, erlotinib, and/or mixtures thereof; wherein R]§ is a peptide.</p>
申请公布号 WO2013033430(A1) 申请公布日期 2013.03.07
申请号 WO2012US53189 申请日期 2012.08.30
申请人 WAKE FOREST SCHOOL OF MEDICINE;BIERBACH, ULRICH;DING, SONG 发明人 BIERBACH, ULRICH;DING, SONG
分类号 A61K31/282;A01N43/62;C07D219/00 主分类号 A61K31/282
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