发明名称 |
IMPROVED CELL CULTIVATION PROCESS |
摘要 |
This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product quality. |
申请公布号 |
EP2563906(A2) |
申请公布日期 |
2013.03.06 |
申请号 |
EP20110715933 |
申请日期 |
2011.04.25 |
申请人 |
NOVARTIS AG |
发明人 |
JOOSTEN, CHRISTOPH E.;LEIST, CHRISTIAN;SCHMIDT, JOERG |
分类号 |
C12N5/02 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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