| 摘要 |
1,267,533. Steroidal lactones. E. R. SQUIBB & SONS Inc. 17 March, 1969 [1 April, 1968], No. 13889/69. Heading C2C. Estrololactone is prepared by subjecting 19- nortestosterone or estr-4-ene-3,17-dione to the action of enzymes of Aspergillus flavipes, A. tamarii, Penicillium chrysogenum, P. citrinum or P. lilacinum and subjecting the 19-nortestololactone thus obtained to the action of enzymes of Corynebacterium simplex, Nocardia restrictus, Pseudomonas testosteroni, Cylindrocarpon radicicola or Mycobacterium rhodochrous. Estrololactone is said to possess antiestrogenic activity and may be made up with carriers into pharmaceutical compositions for oral and parenteral administration.
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