Disclosed herein are methods for decreasing Factor 12 and treating or preventing inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include hereditary angioedema (HAE). Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for developing an inflammatory condition, such as, hereditary angioedema.
申请公布号
WO2012170947(A3)
申请公布日期
2013.02.21
申请号
WO2012US41747
申请日期
2012.06.08
申请人
ISIS PHARMACEUTICALS, INC.;BHATTACHARJEE, GOURAB;REVENKO, ALEXEY;MACLEOD, ROBERT, A.
发明人
BHATTACHARJEE, GOURAB;REVENKO, ALEXEY;MACLEOD, ROBERT, A.