| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide optically active α-hydroxyketones useful as intermediates for medicine, agricultural chemicals, perfumes, etc. <P>SOLUTION: Optically active α-hydroxyketones are produced with a high yield and a high enantio-selectivity by an asymmetric catalytic aldol reaction of an α-ketoaldehyde with another aldehyde. The asymmetric catalyst is preferably a proline derivative. The production method has high versatility for substrates and enables easy synthesis of optically active α-hydroxyalkylketones which have so far been difficult to synthesize. Utilization of the reactivity of optically active α-hydroxyketones produced enables increasing the number of C-C bonds and converting them into polyols. <P>COPYRIGHT: (C)2013,JPO&INPIT |
