发明名称 |
Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto |
摘要 |
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
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申请公布号 |
US8377667(B2) |
申请公布日期 |
2013.02.19 |
申请号 |
US201113109732 |
申请日期 |
2011.05.17 |
申请人 |
GENOMATICA, INC.;HASELBECK ROBERT;TRAWICK JOHN D.;NIU WEI;BURGARD ANTHONY P. |
发明人 |
HASELBECK ROBERT;TRAWICK JOHN D.;NIU WEI;BURGARD ANTHONY P. |
分类号 |
C12P7/02;C12N1/21;C12N9/02;C12N15/00;C12P21/00 |
主分类号 |
C12P7/02 |
代理机构 |
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地址 |
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