RECOMBINANT DNA ELEMENTS FOR THE EXPRESSION OF RECOMBINANT PROTEINS IN A HOST CELL

摘要

Reagents and methods are provided that allow for art Improved expression of a recombinant protein. More specifically, the Introduction of recombinant DNA elements into a host coll allows for the increased expression of a recombinant protein, an improvement of the correct folding of said protein and an increase in cell viability and proliferation of the host cell. These recombinant DNA elements can be introduced into host cells, for example, via a recombinant baculovirus, which has incorporated said elements. The recombinant DNA elements include nucleic acids encoding transcriptional regulators, such as IE-0 and IE-1, transcriptional enhancer elements, such as the homologous region (hr) and promoters.