发明名称 |
A PHARMACEUTICAL COMPOSITION FOR INHIBITING METASTASIS COMPRISING SIRNA OF BC200 RNA |
摘要 |
PURPOSE: An siRNA which suppresses BC200 RNA activation and a pharmaceutical composition containing the same for suppressing tumor metastasis are provided to inhibit cancer cell migration and metastasis and to effectively treat cancer. CONSTITUTION: An siRNA which suppresses BC200 RNA(sequence number 1) activation has a base sequence of 5'-GUAACUUCCCUCAAAGCAA-3'(sequence number 2) or 5'- UUGCUUUGAGGGAAGUUAC-3'(sequence number 3). The siRNA additionally contains a dTdT base sequence at the 3'-end of the siRNA. A vector contains a polynucleotide which enables transcription of shRNA. The vector transcribes shRNA in a cell and the transcribed shRNA is converted into siRNA by cleavage using RNase III. A pharmaceutical composition for suppressing tumor metastasis contains the vector as an active ingredient. The composition additionally contains a pharmaceutically acceptable carrier. [Reference numerals] (AA) Negative control group siRNA
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申请公布号 |
KR20130013675(A) |
申请公布日期 |
2013.02.06 |
申请号 |
KR20110075419 |
申请日期 |
2011.07.28 |
申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
LEE, YOUNG HOON;LEE, JUNG MIN;JUNG, EUI HAN;KIM, YOUNG MI;SHIN, HEE GWON |
分类号 |
A61K31/7105;A61K38/16;A61K38/17;A61P35/00 |
主分类号 |
A61K31/7105 |
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