发明名称 |
SOLID DISPERSION CONTAINING CILOSTAZOL AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
PURPOSE: A solid dispersion of cilostazol and polymethacrylate copolymers, and a pharmaceutical composition containing the same are provided to quickly release cilostazol and to reduce the dosage. CONSTITUTION: A solid dispersion with polymethacylate copolymers contains cilostazol. The copolymer is a copolymer of methacrylic acid and methyl methacrylate, a copolymer of methacrylic acid and ethyl acrylate, an ammonio methacrylate, or a copolymer of butyl methacrylate, (2-dimethyl aminoethyl)methacrylate, and methyl methacrylate. The solid dispersion additionally contains one or more polymers selected from a group consisting of hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, crospovidone, or a copolymer of vinylpyrrolidone and vinyl acetate. An oral pharmaceutical composition contains the solid dispersion and a pharmaceutically acceptable additive. [Reference numerals] (AA) Elution rate(%); (BB) Comparative embodiment 9; (CC) Comparative embodiment 10; (DD) Pletaal Tab.; (EE) Embodiment 7; (FF) Time(h)
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申请公布号 |
KR20130013157(A) |
申请公布日期 |
2013.02.06 |
申请号 |
KR20110074618 |
申请日期 |
2011.07.27 |
申请人 |
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY |
发明人 |
CHOI, HOO KYUN;CHUN, MYUNG KWAN;PARK, JUN HYUNG |
分类号 |
A61K31/4709;A61K31/47;A61K47/38;A61K47/48 |
主分类号 |
A61K31/4709 |
代理机构 |
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