INOSITOL DERIVATIVE AND USE OF THE SAME IN TREATMENT OF DISEASE CHARACTERIZED BY ABNORMAL PROTEIN FOLDING OR AGGREGATION OR AMYLOID FORMATION, DEPOSITION, ACCUMULATION OR PERSISTENCE

摘要

PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for treating diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence.

SOLUTION: Inositol derivatives represented by structural formula I wherein X is a radical of scyllo-inositol wherein R1, R2, R3, R4, R5, and R6are as defined in the specification, or pharmaceutically acceptable salts thereof are described. The compounds, compositions comprising the compounds and methods using the compounds for use in the prevention and/or treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence are also described.

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