FUSED PROTEIN OF TELOMERASE REVERSE TRANSCRIPTASE, NUCLEOTIDES CODING THEM, AND USING THEM

摘要

FIELD: medicine.SUBSTANCE: what is presented is a polynucleotide coding a fused protein of telomerase reverse transcriptase (TERT) wherein an inactive version of TERT polypeptide is combined with a considerable portion of a subunit B of a heat-labile enterotoxin (LTB). It is shown that the fused protein under the invention induces an immune response in a mammal which in the preferential versions of the implementation is stronger than that induced by isolated wild-type TERT.EFFECT: invention discloses preparing the fused protein with the version of hTERT and necessary genetic structures, particularly adenovirus vectors and plasmids, as well as host cells providing expression of a polynucleotide coding the fused protein under the invention.7 cl, 19 dwg, 14 ex