| 摘要 |
591847 Disclosed 2-(phenylamino)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid amides as represented by the general formula (I), wherein each Q2, Q3, Q3a and Q4 are each selected from C and N, the carbon atom being substituted by a substituent as defined herein; A represents aryl, heteroaryl, heterocycloalkyl, cycloalkyl, alkyl, alkenyl or alkynyl, all of which are optionally substituted by one or more substituents selected from R9; and wherein the remaining substituents are as defined herein. Representative compounds include 2-(2,6-dichloro-phenylamino)-3H-imidazo[4,5-c]pyridine-6-carboxylic acid (4,4-dimethyl-cyclohexyl)-amide, 2-(2,6-dichloro-phenylamino)-3H-imidazo[4,5,c]pyridine-6-carboxylic acid cyclohexylamide, N-(4-Bromophenyl)-2-(2-chloro-6-fluoro-phenylamino)-3-methyl-3Himidazo[4,5-c]pyridine-6-carboxamide, 2-(3,5-dichloropyridin-4-ylamino)-N-(4,4-dimethylcyclohexyl)-3-methyl-3H-imidazo[4,5-c]pyridine-6-carboxamide, N-(4-cyclopropylpyridin-2-yl)-2-(2,6-dichlorophenylamino)-1Himidazo[4,5-c]pyridine-6-carboxamide. Further disclosed is a medicament which comprises a compound as defined above for the treatment of asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, inflammatory bowel disease, irritable bowel syndrome, pain, inflammatory pain, fever, migraine, headache, low back pain, fibromyalgia, a myofascial disorder, a viral infection, a bacterial infection, a fungal infection, dysmenorrhea, a burn, a surgical or dental procedure, a malignancy, hyperprostaglandin E syndrome, classic Bartter syndrome, atherosclerosis, gout, arthritis, osteoarthritis, juvenile arthritis, rheumatoid arthritis, rheumatic fever, ankylosing spondylitis, Hodgkin's disease, systemic lupus erythematosus, vasculitis, pancreatitis, nephritis, bursitis, conjunctivitis, iritis, scleritis, uveitis, wound healing, dermatitis, eczema, psoriasis, stroke, diabetes mellitus, a neurodegenerative disorder, an autoimmune disease, an allergic disorder, rhinitis, an ulcer, coronary heart disease, sarcoidosis, any other disease with an inflammatory component, osteoporosis, osteoarthritis, Paget's disease, a periodontal disease or a cancer. |
