PROCEDE D'IMMOBILISATION D'ACIDES NUCLEIQUES

摘要

Process for immobilizing nucleic acids comprising at least one reactive amine function by grafting on a solid support having active carboxylic acid groups, comprises coupling of nucleic acids on the active solid support of pH less than 4.5. Independent claims are included for: (1) support comprising nucleic acids immobilized by chemical grafting, obtainable by the process; and (2) process for purifying a target ligand with affinity support comprising contacting a composition to be purified comprising a target ligand of interest with the affinity support to form a complex between (i) nucleic acids grafted on the support and (ii) the target ligand and releasing the target ligand from the complex formed above and recovering the purified target ligand.