| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a manufacturing method of a substrate facilitating a ligand immobilization operation to a substrate and easily assuring reproducibility of a ligand immobilization ratio, and to provide the substrate and an intermolecular interaction detecting method. <P>SOLUTION: The manufacturing method of ligand immobilization substrates includes: a step (a) for preparing a substrate having a surface comprising SiN (silicon nitride); a step (b) for introducing at least one modified group selected from groups of an epoxy group, an azido group, an isocyanate group, and an isothiocyanate group into the substrate surface comprising SiN (silicon nitride); and, effectively, a step (c) for immobilizing ligands including at least one reactive group selected from groups comprising a thiol group, an amino group, and a hydroxyl group on the surface of the substrate via the reaction between the reactive group and the modified group. <P>COPYRIGHT: (C)2013,JPO&INPIT |
