发明名称 |
SYSTEMS AND METHODS FOR DETERMINING PROPERTIES THAT AFFECT AN EXPRESSION PROPERTY VALUE OF POLYNUCLEOTIDES IN AN EXPRESSION SYSTEM |
摘要 |
A method of designing a polynucleotide sequence encoding a polypeptide sequence of a predetermined polypeptide is provided. A frequency lookup table corresponding to an expression system is obtained. The table comprises a plurality of sequence elements and a plurality of frequency ranges, each frequency range for a corresponding sequence element. Each frequency range is a range of frequencies with which a corresponding sequence element can occur in a polynucleotide. The polynucleotide sequence is defined using the frequency lookup table by determining, for each respective sequence element in the frequency lookup table, whether the respective sequence element encodes a portion of the polypeptide sequence. When the respective sequence element encodes a portion of the polypeptide sequence, the sequence element is incorporated into the polynucleotide at a frequency of occurrence that is within the frequency range specified for the respective sequence element in the lookup table. |
申请公布号 |
EP2294407(A4) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20090758779 |
申请日期 |
2009.06.05 |
申请人 |
DNA TWOPOINTO INC. |
发明人 |
WELCH, MARK;GUSTAFSSON, CLAES |
分类号 |
G06F19/20;C12N15/67;G06F19/22 |
主分类号 |
G06F19/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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