发明名称 |
Optimized antibodies that target CD19 |
摘要 |
The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of using said antibodies. |
申请公布号 |
EP2383297(B1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20110173336 |
申请日期 |
2007.08.14 |
申请人 |
XENCOR INC. |
发明人 |
BERNETT, MATTHEW J.;CHU, SEUNG YUP;DESJARLAIS, JOHN R.;KARKI, SHER BAHADUR;LAZAR, GREGORY ALAN;PONG, ERIK WEIKING;RICHARDS, JOHN O.;ZHUKOVSKY, EUGENE ALEXANDER |
分类号 |
C07K16/28;C07K16/46;C12N15/13 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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