发明名称 |
A PROCESS FOR THE PREPARATION OF TELMISARTAN |
摘要 |
<p>The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl 1H-benzimidazole ii) Treating 4-methyl-6-(1-methylbenzimidazol-2-yl)-2-n-propyl-1H-benzimidazole with 4′-(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.</p> |
申请公布号 |
EP1912975(B1) |
申请公布日期 |
2013.01.16 |
申请号 |
EP20060780538 |
申请日期 |
2006.07.19 |
申请人 |
MATRIX LABORATORIES LTD |
发明人 |
CHAVA, SATYANARAYANA;GORANTLA, SEETA RAMANJANEYULU;GINJUPALLI, SAI PRASANNA B. L. |
分类号 |
C07D403/04;C07D235/20 |
主分类号 |
C07D403/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|