| 摘要 |
Synthetic routes for preparation of a chemical compound containing two linked iodinated phenyl groups and in particular, novel syntheses of loforminol (5,5 -(2-hydroxypropane-1,3-diyl)bis(formylazanediyl)bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)), a contrast agent useful in X-ray imaging. The starting material of the syntheses is 5- amino-2,4,6-triiodoisophthalic acid. 5-Formamido-2,4,6-triiodoisophthaloyl dichloride or 5-Formamido-2,4,6-triiodoisophthalic acid may be intermediates in the preparation. Also shown is 5-Formamido-2,4,6-triiodoisophthaloyl dichloride per se and a process for preparation of an X-ray contrast agent using 5-Formamido-2,4,6-triiodoisophthaloyl dichloride or 5-Formamido-2,4,6-triiodoisophthalic acid as starting material or as an intermediate.
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