METHOD FOR PRODUCING PROTEIN PREPARATION

摘要

Provided is a method for producing a virus-removed protein preparation, comprising a filtration step (a) of filtrating a virus-containing protein solution using a pore virus removal membrane to produce a virus-removed protein solution, wherein the filtration step (a) comprises a low-pressure filtration step (q) of filtrating the solution using the pore virus removal membrane at a filtration pressure of 0.30 kgf/cm2 or less to produce the virus-removed protein solution, and wherein the pH value (X) of the solution before the filtration and the ionic strength (Y (mM)) of a salt in the low-pressure filtration step (q) fulfill both formula (1) 0 = Y = 150X-590 and formula (5) 3.5 = X = 8.0 or both formula (4) Y = 0 and formula (5) 3.5 = X = 8.0.