摘要 |
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I. |
申请人 |
CHENG YUAN;POWERS TIMOTHY;ASHTON KATE;BROWN JAMES;HARRIED SCOTT;HITCHCOCK STEPHEN A.;JUDD TED;LOPEZ PATRICIA;NIXEY THOMAS;PARAS NICK A.;POON STEVE F.;ST. JEAN, JR. DAVID J.;XUE QIUFEN;ZHONG WENGE;AMGEN INC. |
发明人 |
CHENG YUAN;POWERS TIMOTHY;ASHTON KATE;BROWN JAMES;HARRIED SCOTT;HITCHCOCK STEPHEN A.;JUDD TED;LOPEZ PATRICIA;NIXEY THOMAS;PARAS NICK A.;POON STEVE F.;ST. JEAN, JR. DAVID J.;XUE QIUFEN;ZHONG WENGE |