发明名称 |
Recombinant human G-CSF dimer and use thereof for the treatment of neurological diseases |
摘要 |
<p>Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serum half-life and increased biological activity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexes through the pairing of two Fc fragments via disulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fc fragment of human IgG2, and a peptide connecting the G-CSF monomer and the Fc fragment. The rhG-CSF can be used for the treatment of neurological diseases.</p> |
申请公布号 |
AU2011257734(A1) |
申请公布日期 |
2012.12.20 |
申请号 |
AU20110257734 |
申请日期 |
2011.05.25 |
申请人 |
GENERON (SHANGHAI) CORPORATION LTD. |
发明人 |
YAN, XIAOQIANG;HUANG, ZHIHUA;YANG, HONGZHOU;SUN, BILL N.C.;HUANG, YULIANG |
分类号 |
C07K19/00;A61K38/19;A61P25/00;C07K14/535;C12N15/62;C12N15/63 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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