发明名称 |
BENZYLPYRROLIDINONE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
摘要 |
<p>The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.</p> |
申请公布号 |
EP2534158(A1) |
申请公布日期 |
2012.12.19 |
申请号 |
EP20110704004 |
申请日期 |
2011.02.08 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
MANGION, IAN, K.;CARTER, PERCY, H.;DUAN, JINGWU;TEBBEN, ANDREW J. |
分类号 |
C07D498/04;A61K31/4025;A61K31/538;A61P19/00;A61P29/00;C07D207/27 |
主分类号 |
C07D498/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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