| 发明名称 |
INDOLE DERIVATIVE AS CRAC MODULATOR |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compounds useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium channels. <P>SOLUTION: There are provided the compounds represented by formula I or pharmaceutically acceptable salts thereof: wherein R<SP POS="POST">1</SP>is phenyl substituted selected from: 1-6C alkyl; 1-6C alkoxy; halo; halo-1C-6alkyl; halo-1C-6alkoxy; nitrile; acetyl or the like; R<SP POS="POST">2</SP>is 3-6C cycloalkyl; phenyl substituted selected from: 1-6C alkyl; 1-6C alkoxy; 1-6C alkoxyhydroxy; halo; halo-1C-6alkyl; halo-1C-6alkoxy; nitrile or the like; R<SP POS="POST">3</SP>is hydrogen; R<SP POS="POST">3'</SP>is hydrogen or 1-6C alkyl; n is 0-3; each R<SP POS="POST">4</SP>is independently selected from: hydrogen; 1-6C alkyl; 1-6C alkoxy; halo; and halo-1-6C alkyl; and a dashed line is a bond or absent. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2012246302(A) |
申请公布日期 |
2012.12.13 |
| 申请号 |
JP20120180132 |
申请日期 |
2012.08.15 |
| 申请人 |
F HOFFMANN LA ROCHE AG |
发明人 |
ALAM MUZAFFAR;DU BOIS DAISY JOE;HAWLEY RONALD CHARLES;KENNEDY-SMITH JOSHUA;MINATTI ANA ELENA;PALMER WYLIE SOLANG;SILVA TANIA;WILHELM ROBERT STEPHEN |
| 分类号 |
C07D209/10;A61K31/404;A61K31/41;A61K31/4155;A61K31/422;A61K31/4245;A61K31/427;A61K31/4439;A61K31/454;A61K31/496;A61K31/501;A61K31/506;A61K31/5377;A61P11/00;A61P11/06;A61P11/08;A61P19/02;A61P29/00;A61P37/06;A61P43/00;C07D209/12;C07D209/18;C07D401/04;C07D401/14;C07D403/04;C07D403/10;C07D403/14;C07D405/14;C07D409/04;C07D413/10;C07D413/14;C07D417/04;C07D417/14 |
主分类号 |
C07D209/10 |
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